Dr Paul Donnelly

Senior Lecturer

Email: pauld@unimelb.edu.au
Location: Room 506, Bio21 Molecular Science and Biotechnology Institute
Address: Bio21 Institute, School of Chemistry, The University of Melbourne, Victoria 3010, Australia
Phone No: 8344 2399

Find an Expert page: www.findanexpert.unimelb.edu.au/researcher/person97917.html
Donnelly Research group page: donnelly.chemistry.unimelb.edu.au


Profile

  • BSc(Hons), University of Western Australia
  • PhD, University of Western Australia
  • Senior Lecturer, University of Melbourne
  • ARC Future Fellow, University of Melbourne

Areas of Interest

Inorganic Chemistry

  • coordination chemistry
  • bioinorganic chemistry
  • metal ions in biology
  • transition metal chemistry

Molecular Design and Synthesis

  • synthetic chemistry
  • ligand synthesis
  • macrocycles

Research

Metals in Medicine and Biology

Research in the Donnelly Group broadly focuses on the application of synthetic inorganic/organic chemistry to biology and materials science. In particular, the application of coordination chemistry to metal-based drugs and the study of metal ions in biological systems.

One of the principle objectives is the development of new radiopharmaceuticals for analysis and diagnosis. This involves organic synthesis of specifically designed ligands to complex certain metal radionuclides and allow selective delivery of radiation to disease sites. Our current projects focus on copper, rhenium and technetium systems. This radiation can be used for either diagnostic imaging analysis or therapy of the disease. Further selectivity can be achieved by tethering biologically active molecules, such as site-specific peptides to the complexes.

Another major project focuses on the design, synthesis and characterisation of copper and zinc complexes for the treatment of Alzheimer's disease. Our work in collaboration with Drs Barnham and White (Dept of Pathology) attempts to better understand molecular aspects of the condition.

The research group is based in new 'state of art' laboratories in the $100 million Bio21 Institute of Molecular Science and Biotechnology building that opened in 2005. This exciting development provides state-of-the-art facilities for researchers in a dynamic interdisciplinary environment.

Publications

A list of publications produced since 2001 can be viewed at - Find an Expert