Publications
2009
(52)
(51) Bojarová, P., Williams, S.J., ‘Aryl
sulfamates are broad spectrum inactivators of sulfatases: Effects on sulfatases
from various sources’, Bioorg. Med. Chem.
Lett., accepted 13 Nov 2008.
(50) Loft, K.J., Bojarová, P., Slámová, K., Křen,
V., Williams, S.J., ‘Synthesis of sulfated glucosaminides for
profiling substrate specificities of sulfatases and fungal b-N-acetylhexosaminidases’, ChemBioChem, accepted 25 Oct 2008.
(49) Williams, S.J., 'Glycoconjugate
Structure and Biosynthesis', in 'Wiley Encyclopedia of Chemical Biology', Ed.
Begley, T.P., 2009, John Wiley and Sons, in press.
(48) Stick,
R.V., and Williams, S.J.,
‘Carbohydrates. The Essential Molecules of Life', 2009, 474 pages, ISBN
978-0-240-52118-3, Elsevier,
2008
(47) Watt, J.A., Gannon, C.T., Loft, K.J., Dinev,
Z., and Williams, S.J., ‘“Click” preparation of
carbohydrate 1-benzotriazoles, 1,4-disubstituted and 1,4,5-trisubstituted triazoles
and their utility as glycosyl donors’, Aust.
J. Chem., 2008, 61, 837-846.
(46)
(45) Bojarová, P., and Williams,
S.J., 'Sulfotransferases, sulfatases and formylglycine-generating enzymes:
a sulfation fascination', Curr. Opin. Chem. Biol., 2008, 12, 573-581. [link]
(44) McGill,
N., and Williams, S.J., 'Anhydro
sugars' in .Glycoscience: Chemistry and Chemical Biology', Ed. Fraser-Reid,
B.O., Tatsuta, K., Thiem, J., Coté, G.L., Flitsch, S., Ito, Y., Kondo, H.,
Nishimura, S.-i., Yu, B., 2nd Ed, 2008, Vol. I, Springer:
(43) Bojarova, P., Denehy, E., Walker, I., Loft,
K., De Souza, D.P., Woo, L.W., Potter, B.V.L., McConville, M.J., Williams,
S.J., ‘Direct Evidence for ArO-S Bond Cleavage upon Inactivation of Pseudomonas aeruginosa Arylsulfatase by
Aryl Sulfamates’, ChemBioChem, 2008, 9,
613-623. [link]
(42) Qin, C., Chen, X., Hughes, R.A., Williams,
S.J., Woodman, O.L., ‘Understanding the cardioprotective effects of
flavonols: Discovery of relaxant flavonols without antioxidant activity’, J. Med. Chem., 2008, 51,
1874-1884. [link]
(41) Donnelly, P.S.,
2007
(40) Dinev, Z., Gannon, C. T., Egan, C., Watt, J. A., McConville, M. J.
and Williams, S. J., 'Galactose-derived phosphonate analogues as
potential inhibitors of phosphatidylinositol biosynthesis in mycobacteria', Org. Biomol. Chem., 2007, 5,
952-959. [link]
(39) Senaratne, R.H., Mougous, J.D., Reader, J.R., Williams, S.J.,
Zhang, T., Bertozzi, C.R. and Riley, L.W., 'Vaccine efficacy of attenuated but
persistent Mycobacterium tuberculosis
cysH mutant', J. Med. Microbiol.,
2007, 56, 454-458. [link]
(38) Wicki, J., Williams, S.J., Withers, S.G., ‘Transition-State
Mimicry by Glycosidase Inhibitors: A Critical Kinetic Analysis’, J. Am. Chem. Soc., 2007, 129, 4530-4531. [link]
(37) Denehy, E., White, J.M., Williams, S.J.,
‘The electronic structure of the sulfonyl and
phosphonyl groups: A computational and crystallographic study’, Inorg. Chem., 2007, 46,
8871-8886. [link]
(36) Loft, K. and Williams, S.J.,
'Complex carbohydrate modifying enzymes' in 'Glycobiology', Ed. C. Sansom and
O. Markman. 2007, pp.202-216, Scion: Bloxham:
2006
(35) Denehy, E., White, J.M., and Williams, S.J.,
‘Ground state structures of sulfate monoesters and
sulfamates reveal similar reaction coordinates for sulfuryl and sulfamyl
transfer’, Chem. Commun., 2006,
314-316.
[link]
(34) Williams, S.J., Hekmat, O., and
Withers, S.G., ‘Synthesis and testing of mechanism-based protein profiling
probes for retaining endo-glycosidases’, ChemBioChem,
2006, 7, 116-124. [link]
(33) Senaratne,
R.H., De Silva, D., Williams, S.J., Mougous, J.D., Reader, J.R., Zhang,
T., Chan, S., Sidders, B., Lee, D.H., Chan, J., Bertozzi, C.R., Riley, L.W.,
‘5’-Adenosinephosphosulfate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic
infection phase in mice’, Mol. Microbiol.,
2006, 59, 1744-1753. [link]
(32) Dinev, Z., Wardak, A.Z., Brownlee, R.T.C., and Williams, S.J.,
‘A convenient gram-scale synthesis of uridine diphospho(13C6)glucose”
Carbohydr. Res., 2006, 341, 1743-1747. [link]
(31) Sernee, F. M., Ralton, J. E., Dinev, Z., Khairallah, G. N., O'Hair,
R. A. J., Williams, S. J. and McConville, M. J., ‘Biosynthesis of Leishmania mannan is primed by a novel
mannose-cyclic phosphate’, Proc. Natl. Acad. Sci., 2006, 103, 9458-9463. [link]
(30) van der Peet, P., Gannon, C.T., Walker, I., Dinev, Z., Angelin, M.,
Tam, S., Ralton, J.E., McConville, M.J., and Williams, S.J., “Use of click
chemistry to define the substrate specificity of Leishmania b-1,2-mannosyltransferases”, ChemBioChem,
2006, 7, 1384-1391. [link]
2005
(29) Watt, J.A., and
Williams, S.J., ‘Rapid, iterative
assembly of octyl a-1,6-oligomannosides and their 6-deoxy equivalents’, Org. Biomol. Chem., 3.
2005, 1982-1992. [link]
(28) Y. S. Morita,
R. Velasquez, E. Taig, R. F. Waller, J. H. Patterson, D. Tull, S. J. Williams, H. Billman-Jacobe, and
M. J. McConville,, ‘Compartmentalization of lipid biosynthesis in mycobacteria’
J. Biol. Chem., 2005, 280,
21645-21652. [link]
(27) Hekmat,
O., Kim, Y-W., Williams, S.J., He, S., and Withers, S.G.,
‘Active-site peptide ‘fingerprinting’ of glycosidases in complex mixtures by
mass spectrometry: Discovery of a previously undiscovered retaining b-1,4-glycanase in Cellulomonas fimi’, J. Biol. Chem., 2005, 280, 35126-35135. [link]
(26) Williams, S.J. ‘Trifluoromethanesulfonic
anhydride’ in ‘Handbook of Reagents for Organic Synthesis: Reagents for Glycoside,
Nucleotide, and Peptide Synthesis’, Ed. Crich, D., 2005, pp. 634-642, John
Wiley and Sons:
2004
(25) Woodruff, P.J.,
Carlson, B.L., Siridechadilok, B., Pratt, M.R., Williams, S.J., Bertozzi C.R., ‘Trehalose is required for growth of
Mycobacterium smegmatis’ J. Biol. Chem. 2004, 279, 28835-28843. [link]
(24) Gloster, T., Williams, S.J., Roberts, S.,
2003
(23) Gloster, T., Williams, S.J., Tarling, C., Roberts, S., Dupont, C.,
Jodoin, P., Shareck, F., Withers, S.G., and Davies,
G.J.,
‘A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its
amide tautomer’ Chem. Commun., 2003,
944-945. [link]
(22) Williams,
S.J., and Best, J.D., ‘Novel microsomal triglyceride transfer protein inhibitors’ Expert
Opin. Therapeutic Pat., 2003, 13,
479-488.
2002
(21) Notenboom, V., Boraston, A.B. Williams, S.J., Kilburn, D.G., and
Rose, D.R.; ‘High-resolution crystal structures of the lectin-like xylan binding
domain from Streptomyces lividans
Xylanase 10A with bound substrates reveal a novel mode of xylan binding’, Biochemistry, 2002, 41, 4246-4254. [link]
(20) Williams,
S.J., and Withers, S.G., ‘Glycosynthases: Mutant glycosidases for glycoside
synthesis’, Aust.
J. Chem., 2002, 55, 3-12.
(19) Mougous, J.D., Green, R.E., Williams, S.J., Brenner, S.E., and
Bertozzi, C.R., ‘Sulfotransferases and sulfatases in mycobacteria’, Chemistry and Biology, 2002, 9, 767-776. [link]
(18) Williams,
S.J., Senaratne, R.H., Mougous, J.D., Riley, L., and Bertozzi, C.R.,
‘5’-Adenosinephosphosulfate lies at a metabolic branchpoint in mycobacteria’, J. Biol. Chem., 2002, 277, 32606-32615. [link]
(17) Williams,
S.J., Mark, B., Vocadlo, D.J., James, M.N.G., and Withers, S.G., ‘Aspartate
313 in the Streptomyces plicatus
hexosaminidase plays a critical role in substrate assisted catalysis by
orienting the 2-acetamido group and stabilizing the transition state’, J. Biol. Chem., 2002, 277, 40055-40065. [link]
(16) Mougous, J.D.,
Leavell, M.D., Senaratne, R.H., Leigh, C.D., Williams, S.J., Riley, L.W., Leary, J.A., and Bertozzi, C.R.,
‘Discovery of sulfated metabolites in mycobacteria with a genetic and mass
spectrometric approach’, Proc. Natl.
Acad. Sci. USA, 2002, 99,
17037-17042. [link]
2001
(15) Stick, R.V., and Williams,
S.J., ‘Anomeric Anhydro Sugars’, ‘Glycoscience: Chemistry and Chemical
Biology’, Ed. Fraser-Reid, B.O., Tatsuta, K., and
Thiem, J., 2001, Vol. I, 627-642, Springer-Verlag: Heidelberg.
(14) Williams,
S.J., and Davies, G.J., ‘Protein-carbohydrate interactions: Learning
lessons from nature’, Trends in
Biotechnology, 2001, 19, 356-362.
[link]
2000
(13) Skelton, B., Stick, R.V., Tilbrook, D.M.G.,
White, A.H., and Williams, S.J.,
‘Investigations into the chemistry of some 1,6-Epithio-
and 1,6-episeleno-b-D-glucopyranoses’, Aust. J. Chem., 2000, 53,
389-397.
(12) Williams,
S.J., Hoos, R., and Withers, S.G., ‘Nanomolar versus millimolar inhibition
by xylobiose-derived azasugars: Significant differences between two
structurally distinct xylanases’, J. Am.
Chem. Soc., 2000, 122,
2223-2235. [link]
(11) Williams,
S.J., Notenboom, V., Wicki, J., Rose, D.R., and Withers, S.G., ‘A new,
simple, high affinity glycosidase inhibitor: analysis of binding through X-ray
crystallography, mutagenesis and kinetic analysis’, J. Am. Chem. Soc., 2000, 122,
4229-4230. [link]
(10) Notenboom, V., Williams, S.J., Hoos, R., Withers, S.G., and Rose, D.R., ‘Detailed
structural analysis of glycosidase/inhibitor interactions: complexes of Cex
from Cellulomonas fimi with
xylobiose-derived aza-sugars’, Biochemistry,
2000, 39, 11553-11563. [link]
(9) Williams,
S.J., and Withers, S.G., ‘Glycosyl fluorides in enzymatic reactions’, Carbohydr. Res., 2000, 327, 27-46. [link]
1995-1999
(8) Stick, R.V., Tilbrook, D.M.G., and Williams, S.J., ‘b-Acarbose VIII:
The synthesis of some N-linked carba-oligosaccharides’, Aust. J. Chem., 1999, 52,
895-904.
(7) Stick, R.V., Tilbrook, D.M.G., and Williams, S.J., ‘b-Acarbose
(6) Stick, R.V., Tilbrook, D.M.G., and Williams, S.J., ‘1,6-Epithio-
and 1,6-episeleno-b-D-glucopyranose: Useful adjuncts in the synthesis of
6-deoxy-b-D-glucosides’, Aust. J. Chem., 1999, 52, 685-693.
(5) Stick, R.V., Tilbrook, D.M.G., and Williams, S.J., ‘The synthesis of some
seleno- and telluro-b-D-glucopyranosides’, Aust.
J. Chem, 1997, 50, 233-235.
(4) Stick, R.V.,
Tilbrook, D.M.G., and Williams, S.J.,
‘The selective activation of telluro- over seleno-b-D-glucopyranosides
as glycosyl donors: An activity scale for various telluro-, seleno- and
thio-sugars’, Aust. J. Chem, 1997, 50, 237-240.
(3) Stick, R.V.,
Tilbrook, D.M.G., and Williams, S.J.,
‘1,6-Epithio- and 1,6-episeleno-b-D-glucopyranose:
Useful adjuncts in the synthesis of 6-deoxy-b-D-glucosides’, Tetrahedron Lett., 1997, 38,
2741-2744.
(2) Bouchet, F.,
Driguez, H., McAuliffe, J.C., Stick, R.V., Tilbrook, D.M.G., and Williams S.J., ‘A new approach to some
1,6-dideoxy-1,6-epithio sugars’, Aust. J. Chem., 1996, 49,
343-348.
(1) Brunow, G.,
Stick, R.V., Syrjänen, K., Tilbrook, D.M.G., and Williams S.J., ‘A synthesis of (Z)-9-octadecene-1,18-dioic acid’, Aust.
J. Chem., 1995, 48, 1893-1897.
Patents
(1) Bertozzi, C.R., Williams, S.J.,
Mougous, J.D. ‘Mycobacterial sulfation pathway proteins and methods of use
thereof’, PCT Int. Appl. (2003), US 2003180321.
(2)
(3) Zammit, S., Williams, S.J. and Kelly,
D. J., 'New antifibrotic agents', AU
PCT (2007), AU 004988753.
Book Reviews
(4) Williams, S.J., and
Withers, S.G., ‘Essentials of carbohydrate chemistry and biochemistry’ by
Thisbe Lindhorst’, Book Review, Angew. Chem. Int. Ed., 2000, 39, 3143-3144.
(5) Williams, S.J. “Peptides and proteins’
by Shawn Doonan, Book Review, Aust. J.
Chem., 2003, 56, 839.
Commentary
(6) Williams, S.J., Davies, G.J. “A master
of its sulfate”, Nature Struct. Mol.
Biol., 2004, 11, 686-687.
Commentary for “Identification, function and structure of the mycobacterial
sulfotransferase that initiates sulfolipid-1 biosynthesis’.
[link]
Graphical summary
